So its role in Low-T is another reason to commit to healthier lifestyle choices and weight reduction. This was discussed in a 2014 review article that looked at several studies on testosterone therapy. The link was so strong that the researchers recommended using waist circumference as the preferred measurement for predicting testosterone levels before conducting lab tests. In a similar 2004 study of more than 1,500 men aged 25 to 84, the researchers noted that waist circumference, rather than BMI, seemed to be tied to lower testosterone levels. "Some research has shown an inverse relationship between waist circumference and testosterone levels (i.e., the larger the waist, the lower the testosterone). According to Harvard Health Publishing, waist circumference is the strongest individual predictor of testosterone deficiency. Department of Health and Human Services, protects the public health by assuring the safety, effectiveness, and security of human and veterinary drugs, vaccines and other biological products for human use, and medical devices. The safety and effectiveness of coadministration of Zepbound with other medications for weight management have not been established. These studies measured weight reduction after 72 weeks in a total of 2,519 patients who received either 5 mg, 10 mg or 15 mg of Zepbound once weekly and a total of 958 patients who received once-weekly placebo injections. We process personal information and consumer health data to provide you with our products and services and maintain essential website functionality. Hone-affiliated medical practices are independently owned and operated by licensed physicians who provide services using the Hone telehealth platform. Hone is an online clinic that helps men and women manage their health. If you’re living with low testosterone levels and obesity, the first thing to consider is your lifestyle. Low levels of testosterone affect body composition (ratio of muscle to fat) by decreasing muscle mass. To test this hypothesis, researchers analyzed the electronic health records of 110 adult men with obesity or type 2 diabetes being treated with the weight-loss medications semaglutide, dulaglutide or tirzepatide and who were not on testosterone or hormonal therapy. Anti-obesity medications can significantly raise testosterone levels and improve health outcomes for men with obesity or type 2 diabetes, according to a new study being presented Monday at ENDO 2025, the Endocrine Society’s annual meeting in San Francisco, Calif. Recalling that some of the effects of testosterone include reducing fat mass and increasing muscle mass, it follows that obesity-induced testosterone reduction can also exacerbate obesity. However, whether testosterone treatment increases risk is unknown because there are no adequately designed and powered RCTs that have assessed the long-term risk-benefit ratio of testosterone therapy. Independent healthcare providers review your test results and you will be contacted if they require prompt attention. You will be emailed when they are ready.Discuss your results with an independent healthcare provider at no extra cost. No doctor visit is required for purchase, but an independent healthcare provider is involved throughout the process. Questhealth.com offers 150+ consumer-initiated Quest Diagnostics lab tests to empower you to have more control over your health journey. Symptoms of low testosterone in females are not well characterized. This test will determine whether your total testosterone level is normal, high, or low. This test measures total testosterone, which represents all biological pools of testosterone, including the free forms, as well as those bound to proteins in the blood. In our study of 255 hypogonadal men, we noted 71% of men were obese and 14.1% had obesity grade III, using a testosterone cut-off of 12.1 nmol/l 23▪▪. Furthermore, a number of Food and Drug Administration (FDA)-approved drugs for treatment of obesity have serious adverse side-effects and were taken off the market 12,17. Although lifestyle modifications are highly recommended, as integral part of strategies designed for treatment and management of obesity 5–7, in most patients, such strategies are not always successful in the long term because of high rate of recidivism, in part due to lack of adherence to prescribed regimen 8–11.