Oyster extract has been shown to increase your testosterone levels, improve libido and provide extra immunity. Oysters are completely natural and have impressively high levels of zinc; one of the most important minerals in the male body. This illustrates the ability for oysters to improve your anti-oxidant levels and protect your cells from free radical damage. They are basically protein and saltwater; it is their effect on testosterone levels that makes them a powerful tool for sexual arousal. If you want to increase your testosterone levels then maybe you should learn to love them. The docking scores for dipeptides RI, IR, and VR with ACE were −7.234, −5.855, and −7.836, respectively. Figure 9 presents the results of the testosterone assay conducted on the cell culture supernatant. Notably, the two treatment groups with VR showed the highest cell survival rates among all the interventions. However, under dipeptide intervention, the proportion of apoptotic and necrotic cells exhibited varying degrees of reduction. Figure 3b displays the intracellular ROS content after different concentrations of AAPH treatments. This observation could be attributed to the insufficient production of ROS caused by the significant decrease in cell viability. Consequently, 20 μg/mL and 40 μg/mL concentrations were selected as the final peptide concentrations for subsequent treatments of TM3 cells in the subsequent experiments. Their identification was established by analyzing the parent molecule and fragment ion information and comparing them with oyster protein sequences in the NCBI database. Three dipeptides, namely IR, RI, and VR, were identified from the oyster peptide mixture. D-Aspartic acid is an amino acid which not naturally found in the body; however, it is crucial for the production of testosterone hormone. The study determines the effect of shellfish supplementation on the regulation of male rat reproduction by measuring the testosterone serum level. Oysters are basically filled with protein and salt water and its effect on the testosterone levels is what makes it a popular aphrodisiac. This is an impressive result for any supplement and one that means you need to seriously consider adding oyster extract to your diet. It is also worth noting that if you have a pre-existing medical condition it is advisable to confirm with your doctor before you start taking oyster extract. Most supplements carry a health warning regarding the list of potential side effects.