Performance Insiders does not assume liability for any actions undertaken after visiting these pages and does not assume liability if one misuses supplements. We review published medical research in respected scientific journals to arrive at our conclusions about a product or health topic. Below you'll find some of the most effective male enhancement supplements on the market today, in our opinion. It supports prostate health in men and also helps to control their bladders. Zenesis Saw Palmetto Extract is a great competition among the many supplements which are available in the market. While regulating the urinating frequency of the user, this continues to make the prostate healthy and also helps to reduce its size when it is enlarged.. MacLaughlin, B. W., Gutsmuths, B., Pretner, E., Jonas, W. B., Ives, J., Kulawardane, D. V., and Amri, H. Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models. Prospective study on 320 patients]. Suter A, Saller R, Riedi E, Heinrich M. Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation?|Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. A detailed safety assessment of a saw palmetto extract. Serenoa repens for benign prostatic hyperplasia. Tuncel A, Ener K, Han O, et al. Effects of short-term dutasteride and Serenoa repens on perioperative bleeding and microvessel density in patients undergoing transurethral resection of the prostate. Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.} Effects of long-term treatment with Serenoa repens (Permixon) on the concentrations and regional distribution of androgens and epidermal growth factor in benign prostatic hyperplasia. In vivo effect of the lipido-sterolic extract of Serenoa repens (Permixon) on mast cells accumulation and glandular epithelium trophism in the rat prostate. Induction of apoptosis and inhibition of cell proliferation by the lipido-sterolic extract of Serenoa repens (LSEr, Permixon) in benign prostatic hyperplasia. An urodynamic study of patients with benign prostatic hypertrophy treated conservatively with phytotherapy or testosterone (author's transl). It works by inhibiting the enzyme 5-alpha reductase, which converts testosterone into dihydrotestosterone (DHT). Saw palmetto may cause mild side effects including headaches, dizziness, nausea, and digestive issues. The most common side effects of saw palmetto include digestive issues such as nausea, stomach pain, diarrhea, and constipation. People who should avoid saw palmetto include pregnant or breastfeeding women, children, and those with hormone-sensitive conditions like breast or prostate cancer. However, these side-effects are usually alleviated by taking saw palmetto after food, rather than before. Another more recent study looked at 370 patients and randomized them to three escalating doses to saw palmetto. Saw palmetto is also useful for the treatment of erectile dysfunction. This is because saw palmetto also decreases the uptake of DHT by the hair follicles, and decreases the binding of DHT to androgenetic receptors.